Real-time blackhole lists may be used with ISMail to reject messages from listed IP addresses.
If enabled, RBLs are queried for the IP address of the sender of a message. If the IP is listed, the message will be rejected.
Instructions for enabling RBL support with ISMail, ISMail Pro, and ISMail EP are listed for several RBLs below.
To use ORDB: (screenshot)
To use SpamHaus: (screenshot)